The table below will be updated periodically. This report utilizes the generic name, even though the brand name may be more easily recognized among users in the US and Europe. The exception is the use of the shortened chemical name for some of the nucleoside analogs (a/k/a "nukes;" such as referring to AZT instead of zidovudine or the brand name, Retrovir). This is because the generic or chemical name is the one that counts--and may be of more relevance to international readers. Drugs in italics have not yet been approved by the FDA.


MAINSTREAM ANTIVIRAL DRUG THERAPY

Drug

Dose

Total Pills

Total Daily Dose*

Food restrictions

NUCLEOSIDE ANALOGS (NRTIs, "nukes")

AZT (zidovudine, Retrovir)

1 300 mg capsule twice daily

(would less work as well?)

2

600 mg

none (with food may minimize stomach discomfort)

Combivir (AZT/3TC)

1 tablet, twice daily

2

(600 mg/
300 mg)

none (with food may minimize stomach discomfort); do not take if you weigh less than 110 pounds

Trizivir (AZT, 3TC, abacavir)

1 tablet, twice daily

2

(600 mg,
300 mg)

none (with food may minimize stomach discomfort); do not take if you weigh less than 90-110 pounds

d4T (stavudine, Zerit)

1 capsule twice daily

2

80 mg

none

ddI (didanosine, Videx)

4 tablets, once per day

(New Formulation: 2 tablets once daily)

"Two 100-mg tablets twice a day* (a total of 4 pills a day), or Two 200-mg tablets, once a day (a total of 2 pills a day)."

2

200 mg

Empty stomach, don't eat for one hour after taking (2 hours after, 30 minutes before eating)

3TC (lamivudine, Epivir)

1 tablet, twice daily

2

300 mg

none

ddC (dideoxycytidine, zalcitabine, HIVID)

1 capsule, three times daily

3

2.25 mg

none; probably best on an empty stomach

Abacavir (Ziagen)

1 tablet, twice daily

2

600 mg

none; please see warnings below!

Tenofovir (Viread)

1 daily

1

300 mg

Take with food/high fat meal

FTC (emtricitabine, Coviracil)

1 daily

1

200 mg

none?

DAPD/DXG, amdoxovir

?

bid?

?

? dioxolane purine nukes

         

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIs)

Nevirapine (Viramune)

1 200 mg tablet, twice daily (see below)

2

400 mg

none

Delavirdine (Rescriptor)

4 100 mg tablets, three times a day or 6 tablets, twice daily

12

1200 mg

Don't take with ddI or antacids; no food restrictions

Efavirenz (Sustiva/Stocrin)

3 200 mg capsules, once daily

3

600

Not with high fat meal; take at bedtime for first 2-4 weeks

TMC125

900 mg bid

2?

1,800 mg

ND

DPC 083

300 mg?

1

300 mg?

"son of Sustiva"; probably as Sustiva

Emivirine (Coactinon)

1 tablet, twice per day

2

1,000

none; used with Sustiva Company suspending development

PROTEASE INHIBITORS

Saquinavir (Invirase-hard gel)

Only use with ritonavir if at all; old drug

This is the old hard capsule formula, replaced by soft gel Fortovase.

Saquinavir (Fortovase-soft gel)

8 capsules, twice daily

16

3,200 mg

take within one hour of a meal which includes at least 28 grams of fat. Refrigerate for long-term storage (longer than 3 months). Otherwise, room temperature storage is fine.

Ritonavir (Norvir)

6 capsules, twice daily

12

1,200 mg

With food to minimize side effects, especially high-fat snacks. Store capsules, oral solution at room temperature, but refrigerate in hot weather.

Indinavir (Crixivan)

2 capsules, 3 times per day

6

2,400 mg

2 hours after food and 1 hour before; (empty stomach), or with a light, low-fat snack. Drink at least 48 ounces (six 8-oz. glasses) of water daily to prevent kidney stones.

Nelfinavir (Viracept)

5 tablets, twice daily

10

2,500 mg

take with meal or snack

Amprenavir (Agenerase)

8 tablets, twice daily

16

2,400 mg

With food but not with high fat meal; do not take extra vitamin E (beyond that in a multivitamin)

Lopinavir + ritonavir (Kaletra)

Each capsule, 133 mg lopinavir plus 33 mg of ritonavir. Three capsules twice daily.

6

800/200 mg

take with meal; liquid form is available. Keep refrigerated.

Tipranavir (TPV)

1-2 capsules, twice daily?

2-4?

1,000-2,000

non-peptidic; taken with fatty food

Atazanavir (TAZ)

200, 400 or 600 mg, as tolerated

1

max 600

may cause hyperbilirubinemia

         

FUSION INHIBITORS: gp120, gp41

T20

Binds to gp120; 2 sub-q injections

--

--

2 injections

T1249

 

--

--

2 injections

PRO540

 

ND

ND

ND

chloroquine

Test tube; interaction with gp120

ND

ND

ND

         

FUSION INHIBITORS: ANTI-CCR5, CXCR4

AMD3100

Trial halted, no efficacy

ND

--

Failed.

SCH-C

50-100 mg; every 12 hours

ND

--

 

SCH-D

?

ND

--

 
         

OTHER TARGETS - INTEGRASE, REV:RRE

S-1360

In vitro and mouse data

ND

--

Effective against various isolates, resistant strains; animal studies

neomycin derivative? tobramycin

inhibits rev:rre

ND

--

This is purely theoretical

Tat? Nef targets? Where are they?

 

ND

--

???

ND - No data.


mission | overview | purity/potency | side effects | links | contact
Nepal Project | clinical trial proposals

Copyright FIAR 2002